![]() VEGF angiogenesis coronaries heart regeneration revascularization. The zebrafish heart displays fast revascularization of the damaged area. ( A– C) Tg(fli1a: EGFP) ventricles at 0, 15, and 40 hpi. White arrowheads point to coronary vessel sprouts in the injured area asterisk marks an area of coronary plexus ( n = 4). Insets show high-magnification images of early coronary sprouts ( B) and the coronary plexus ( C). ![]() ( D) Tg(kdrl: EGFP) heart at 15 hpi ( n = 3). ( E and F) Tg(fli1a: EGFP) Tg(kdrl: mCherry) ventricles extracted at 0 hpi and cultured in explant medium for 24 h (0+24 hpi) ( n = 3). White arrowhead points to kdrl:EGFP + vessels sprouting into the injured area. Inset shows overlay image of a sprouting coronary vessel. White arrows point to fli1a:EGFP + /kdrl:mCherry + coronary vessel sprouting into the injured area. ( G) Tg(Dll4in3: TagRFP) ventricle at 40 hpi ( n = 5). ![]() Inset shows a Dll4in3:TagRFP + sprouting coronary artery. ( H and I) Tg(cxcr4a:YFP) ventricles at 40 hpi ( n = 3) and 7 dpi ( n = 4). Insets show cxcr4a:YFP + sprouting coronaries white arrowheads point to coronary arteries sprouting into the injured area. (Scale bars: 50 μm.)Įxpression patterns of different arterial and venous markers at different developmental stages and after injury. ![]() ( A and B) Images of Tg(kdrl: EGFP) ( n = 4) and Tg(-0.8flt1:RFP) ( n = 4) adult caudal fins. ![]()
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